2020-2021 Varsity W. Basketball
| Date | | Opponent | Location | Result | | W/L |
|---|
| Sat, Nov 07
| | Permian | Seminole | 62-34 | | W |
| Permian | Seminole |
| Tue, Nov 10
| | Vega | LCU | 87-53 | | W |
| Vega | LCU |
| Fri, Nov 13
| | Odessa High | Odessa | 71-48 | | W |
| Odessa High | Odessa |
| Sat, Nov 14
| | Midland Christian | Seminole | 66-9 | | W |
| Midland Christian | Seminole |
| Tue, Nov 17
| | Estacado | Seminole | 75-48 | | W |
| Estacado | Seminole |
| Fri, Nov 20
| | New Home | New Home | 74-50 | | W |
| New Home | New Home |
| Mon, Nov 23
| | San Angelo Central | San Angelo | 40-47 | | L |
| San Angelo Central | San Angelo |
| Fri, Dec 04
| | Coronado | Seminole | 76-60 | | W |
| Coronado | Seminole |
| Tue, Dec 08
| | Midland Lee | Midland | 32-38 | | L |
| Midland Lee | Midland |
| Tue, Dec 15
| | Lubbock Christian | Seminole | 53-68 | | L |
| Lubbock Christian | Seminole |
| Fri, Dec 18
| | Cooper | Seminole | 54-74 | | L |
| Cooper | Seminole |
| Sat, Dec 19
| | Monterey | Seminole | 63-48 | | W |
| Monterey | Seminole |
| Mon, Dec 21
| | Sudan | Seminole | 82-54 | | W |
| Sudan | Seminole |
| Tue, Dec 29
| | Crane | Crane | 90-41 | | W |
| Crane | Crane |
| Thu, Dec 31
| | Lubbock High | Lubbock | 70-61 | | W |
| Lubbock High | Lubbock |
| Sat, Jan 02
| | Denver City | Denver City | 58-19 | | W |
| Denver City | Denver City |
| Tue, Jan 05
| | Pecos (District) | Seminole | 92-15 | | W |
| Pecos (District) | Seminole |
| Fri, Jan 08
| | Fort Stockton (District) | Seminole | 88-24 | | W |
| Fort Stockton (District) | Seminole |
| Tue, Jan 12
| | Andrews (District) | Seminole | 65-32 | | W |
| Andrews (District) | Seminole |
| Fri, Jan 15
| 6 p.m. | Monahans | Seminole | | | |
| Monahans | Seminole |
| Tue, Jan 19
| 6 p.m. | Greenwood (district) | Greenwood | | | |
| Greenwood (district) | Greenwood |
| Fri, Jan 22
| 6 p.m. | Pecos (District) | Pecos | | | |
| Pecos (District) | Pecos |
| Tue, Jan 26
| 6 p.m. | Fort Stockton (District) | Fort Stockton | | | |
| Fort Stockton (District) | Fort Stockton |
| Fri, Jan 29
| 6 p.m. | Andrews (District) | Seminole | | | |
| Andrews (District) | Seminole |
| Tue, Feb 02
| 6 p.m. | Monahans (District) | Monahans | | | |
| Monahans (District) | Monahans |
| Fri, Feb 05
| 6 p.m. | Greenwood (District) | Seminole | | | |
| Greenwood (District) | Seminole |
